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selected radiotracer would behave appropriately in humans. During the past 12 years there have been remarkable advances in molecular genetics, molecular biology, synthetic radiopharmaceutical chemistry, molecular modeling and visualization, and emission tomography. Biological models can now be selected that are better defined in terms. 5 Molecular biology, bioinformatics and basic techniques R. RAPLEY Introduction Structure of nucleic acids Genes and genome complexity Location and packaging of nucleic acids Functions of nucleic acids The manipulation of nucleic acids – basic tools and techniques free or attached to another chemical entity as these forms may have a different biodistribution. This is termed the radiochemical purity. In diagnostic scanning the different biodistribution of contaminating radioactive chemicals could interfere with the clinical diagnosis by obscuring the region of interest and.

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